If you don’t know what is happening on your network and need to respond quickly and intelligently to malware and other attacks, you might want to look at SoleraSix from Solera Networks. I took a look at this security appliance for my most recent video screencast review that you find here.
SoleraSix goes way beyond packet capture to provide an impressive collection of analyses to keep pace with advanced persistent threats and the growing sophistication of attackers and abusers.